Article
Molecular evolution of multiple recurrent cancers of the bladder.
Human molecular genetics - 12 Dec 2000
van Tilborg A A, de Vries A, de Bont M, Groenfeld L E, van der Kwast T H, Zwarthoff E C
Abstract excerpt
We describe the reconstruction of bladder tumor development in individual patients spanning periods of up to 17 years. Genomic alterations detected in the tumors were used for hierarchical cluster analysis of tumor subclones. The cluster analysis highlights the clonal relationship between tumors from each patient. Based on the cluster data we were able to reconstruct the evolution of tumors in a genetic tree,...
Topics
- Evolution, Molecular
- Genotype
- Humans
- Loss of Heterozygosity
- Microsatellite Repeats
- Neoplasm Recurrence, Local
- Pedigree
- Phylogeny
- Protein-Tyrosine Kinases
- Receptor, Fibroblast Growth Factor, Type 3
- Receptors, Fibroblast Growth Factor