Article
Mapping and genome sequence analysis of chromosome 5 regions involved in bladder cancer progression.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2001
Kram A, Li L, Zhang R D, Yoon D S, Ro J Y, Johnston D, Grossman H B, Scherer S, Czerniak B
Abstract excerpt
We studied the evolution of allelic losses on chromosome 5 by whole-organ histologic and genetic mapping in 234 mucosal DNA samples of 5 cystectomy specimens with invasive bladder cancer and preneoplastic changes in adjacent urothelium. The frequency of alterations in individual loci was verified on 32 tumors and 29 voided urine samples from patients with bladder cancer. Finally, deleted regions on chromosome 5...
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