Article
Influence of CYP2C19 on the relationship between pharmacokinetics and intragastric pH of omeprazole administered by successive intravenous infusions in Chinese healthy volunteers.
European journal of clinical pharmacology - 1 Jun 2010
Wang Yongqing, Zhang Hongwen, Meng Ling, Wang Meifeng, Yuan Hongyu, Ou Ning, Zhang Haibo, Li Ziyan, Shi Ruihua
Abstract excerpt
OBJECTIVES: To explore the effect of cytochrome P450 2C19 (CYP2C19) polymorphisms on the relationship between the pharmacokinetics and pharmacodynamics of omeprazole administered by intravenous successive infusions in Chinese healthy volunteers. METHODS: A total of 21 subjects [7 homozygous extensive metabolizers (homEMs), 9 heterozygous extensive metabolizers (hetEMs), 5 poor metabolizers (PMs)] received a 5-day...
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