Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.

Journal of virology - 1 Oct 2015

Shin Dai-Lun, Hatesuer Bastian, Bergmann Silke, Nedelko Tatiana, Schughart Klaus

Abstract excerpt

UNLABELLED: Influenza virus infections represent a serious threat to human health. Both extrinsic and intrinsic factors determine the severity of influenza. The MX dynamin-like GTPase 1 (Mx1) gene has been shown to confer strong resistance to influenza A virus infections in mice. Most laboratory mouse strains, including C57BL/6J, carry nonsense or deletion mutations in Mx1 and thus a nonfunctional allele, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchoalveolar Lavage Fluid
Share to Host Specificity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza A Virus, H3N2 Subtype

Share to Mice, Congenic

Share to Mice, Inbred DBA

Share to Myxovirus Resistance Proteins

Share to Orthomyxoviridae Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 26202236
DOI: 10.1128/JVI.01305-15
PMCID: PMC4577889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.PMID 26202236Read ↗

The Mx1 Gene Protects Mice against the Pandemic 1918 and Highly Lethal Human H5N1 Influenza VirusesSemantic proximity Read ↗

Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.Semantic proximity Read ↗

Mx genes: host determinants controlling influenza virus infection and trans-species transmission.Semantic proximity Read ↗

Molecular Signatures Associated with Mx1-Mediated Resistance to Highly Pathogenic Influenza Virus Infection: Mechanisms of SurvivalSemantic proximity Read ↗

Replication fitness determines high virulence of influenza A virus in mice carrying functional <i>Mx1</i> resistance geneSemantic proximity Read ↗

Mx1 Gene Protects Mice Against the Highly Lethal Human H5N1 Influenza VirusSemantic proximity Read ↗

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.Semantic proximity Read ↗

Genetic insertion of mouse Myxovirus-resistance gene 1 increases innate resistance against both high and low pathogenic avian influenza virus by significantly decreasing replication in chicken DF1 cell lineSemantic proximity Read ↗

Protective role of interferon-induced Mx GTPases against influenza virusesSemantic proximity Read ↗

Genetic susceptibility and resistance to influenza infection and disease in humans and mice.Semantic proximity Read ↗

Mx1 but Not MxA Confers Resistance against Tick-Borne Dhori Virus in MiceSemantic proximity Read ↗

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.