Cyclodextrins Inhibit Replication of Scrapie Prion Protein in Cell Culture

Abstract excerpt

Prion diseases are fatal neurodegenerative disorders that are caused by the conversion of a normal host-encoded protein, PrP(C), to an abnormal, disease-causing form, PrP(Sc). This paper reports that cyclodextrins have the ability to reduce the pathogenic isoform of the prion protein PrP(Sc) to undetectable levels in scrapie-infected neuroblastoma cells. Beta-cyclodextrin removed PrP(Sc) from the cells at a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alcoholism and Thiamine Deficiency
• Share to Porphyrin Metabolism and Disorders
• Share to Prion Diseases and Protein Misfolding