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Article

Doxycycline and protein folding agents rescue the abnormal phenotype of familial CJD H187R in a cell model.

Brain research. Molecular brain research - 7 Apr 2004

Gu Yaping, Singh Neena

Abstract excerpt

Familial Creutzfeldt-Jakob disease (CJD) comprises a group of neurodegenerative disorders for which currently there is no treatment. In this study, we evaluated the efficacy of drugs approved for human use, and protein folding agents in reversing the mutant phenotype of familial CJD H187R in a cell model. For an efficient experimental readout, green fluorescent protein (GFP)-tagged mutant prion protein...

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Identifiers

PMID: 15046864
DOI: 10.1016/j.molbrainres.2004.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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