Article
Antiprion activity of cholesterol esterification modulators: a comparative study using ex vivo sheep fibroblasts and lymphocytes and mouse neuroblastoma cell lines.
Antimicrobial agents and chemotherapy - 1 Nov 2007
Pani Alessandra, Norfo Claudia, Abete Claudia, Mulas Claudia, Putzolu Marirosa, Laconi Sergio, Orrù Christina Doriana, Cannas M Dolores, Vascellari Sarah, La Colla Paolo, Dessì Sandra
Abstract excerpt
Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie revealed abnormal accumulation of cholesterol esters in ex vivo peripheral blood mononuclear cells (PBMCs) and skin fibroblasts from healthy and scrapie-affected sheep carrying a scrapie-susceptible genotype compare...
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