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Article

Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.

Journal of virology - 1 Nov 2007

Chung Dong-Hoon, Sun Yanjie, Parker William B, Arterburn Jeffrey B, Bartolucci Al, Jonsson Colleen B

Abstract excerpt

The broad spectrum of antiviral activity of ribavirin (RBV) lies in its ability to inhibit IMP dehydrogenase, which lowers cellular GTP. However, RBV can act as a potent mutagen for some RNA viruses. Previously we have shown a lack of correlation between antiviral activity and GTP repression for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17699579
DOI: 10.1128/JVI.00874-07
PMCID: PMC2168817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-17699579-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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