Article
Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2007
Büsst Cara J, Scurrah Katrina J, Ellis Justine A, Harrap Stephen B
Abstract excerpt
Systolic blood pressure is determined in large part by genes. Six independent studies have reported evidence of linkage between systolic pressure and chromosome 16p12 that incorporates SCNN1G, the gene encoding the gamma-subunit of the epithelial sodium channel. We undertook the first comprehensive association analysis of SCNN1G and systolic pressure. To achieve genetic contrast, we sampled unrelated subjects...
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