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Article

Common variants in epithelial sodium channel genes contribute to salt sensitivity of blood pressure: The GenSalt study.

Circulation. Cardiovascular genetics - 1 Aug 2011

Zhao Qi, Gu Dongfeng, Hixson James E, Liu De-Pei, Rao Dabeeru C, Jaquish Cashell E, Kelly Tanika N, Lu Fanghong, Ma Jixiang, Mu Jianjun, Shimmin Lawrence C, Chen Jichun, Mei Hao, Hamm L Lee, He Jiang

Abstract excerpt

BACKGROUND: Rare mutations of the epithelial sodium channel (ENaC) lead to mendelian forms of salt-sensitive hypertension or salt-wasting hypotension. We aimed to examine the association between common variants in the ENaC genes and salt sensitivity of blood pressure (BP). METHODS AND RESULTS: A total of 1906 Han Chinese participated in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21562341
DOI: 10.1161/CIRCGENETICS.110.958629
PMCID: PMC3157544

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