Article
Association of sodium channel gamma-subunit promoter variant with blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2001
Iwai N, Baba S, Mannami T, Katsuya T, Higaki J, Ogihara T, Ogata J
Abstract excerpt
The SCNN1G gene, located on human chromosome 16p12, encodes the gamma subunit of the amiloride-sensitive epithelial sodium channel, and mutations in SCNN1G can result in Liddle's syndrome or pseudohypoaldosteronism type I. We identified sequence variations in the promoter region of SCNN1G and examined the association between this polymorphism and blood pressure in a large cohort (n=4075) representing the general...
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