Article
Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events.
JAMA - 13 Dec 2006
Lange Leslie A, Carlson Christopher S, Hindorff Lucia A, Lange Ethan M, Walston Jeremy, Durda J Peter, Cushman Mary, Bis Joshua C, Zeng Donglin, Lin Danyu, Kuller Lewis H, Nickerson Deborah A, Psaty Bruce M, Tracy Russell P, Reiner Alexander P
Abstract excerpt
CONTEXT: C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD). OBJECTIVE: To assess whether polymorphisms in the CRP gene are associated with plasma CRP, carotid intima-media thickness (CIMT), and CVD events. DESIGN, SETTING, AND PARTICIPANTS: In the prospective, population-based Cardiovascular Health Study, 4 tag single-nucleotide...
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