Fine mapping of quantitative trait loci affecting organ weights by mouse intersubspecific subcongenic strain analysis.

doi:10.1111/asj.12004

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Article

Fine mapping of quantitative trait loci affecting organ weights by mouse intersubspecific subcongenic strain analysis.

Animal science journal = Nihon chikusan Gakkaiho - 1 Apr 2013

Mollah Md Bazlur Rahman, Ishikawa Akira

Abstract excerpt

The genetic architecture of organ weights is not well understood. In this study, we fine-mapped quantitative trait loci (QTLs) affecting organ weights by characterizing six intersubspecific subcongenic mouse strains with overlapping and non-overlapping genomic regions on chromosome 2 derived from wild Mus musculus castaneus. QTLs for heart, lung, spleen and kidney weights were revealed on a 6.38-Mb genomic region...

Topics

Animals
Mice
Microsatellite Repeats
Models, Statistical
Organ Size
Phenotype
Quantitative Trait Loci

Source

Open in PubMed

Identifiers

PMID: 23590502
DOI: 10.1111/asj.12004

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