Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

Biochemical and biophysical research communications - 12 Oct 2007

Niederberger Ellen, Ehnert Corina, Gao Wei, Coste Ovidiu, Schmidtko Achim, Popp Laura, Gall Charlotte von, Korf Horst Werner, Tegeder Irmgard, Geisslinger Gerd

Abstract excerpt

Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We investigated the impact of spinal CREB protein levels and phosphorylation at Ser142 on the nociceptive behaviour in rat and mouse models of inflammatory nociception....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP Response Element-Binding Protein
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Proto-Oncogene Proteins c-fos

Share to Rats, Sprague-Dawley

Share to Serine

Share to Spinal Cord

Source

Identifiers

PMID: 17692820
DOI: 10.1016/j.bbrc.2007.07.148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.PMID 17692820Read ↗

Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.Semantic proximity Read ↗

MeCP2 Plays an Analgesic Role in Pain Transmission through Regulating CREB / miR-132 PathwaySemantic proximity Read ↗

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.Semantic proximity Read ↗

Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury.Semantic proximity Read ↗

Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.Semantic proximity Read ↗

Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.Semantic proximity Read ↗

Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.Semantic proximity Read ↗

Generation of a conditional CREB Ser133Ala knockin mouse.Semantic proximity Read ↗

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.Semantic proximity Read ↗

Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.