Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.

doi:10.1042/BJ20091630

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Article

Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.

The Biochemical journal - 24 Feb 2010

O'Shea John M, Perkins Neil D

Abstract excerpt

Phosphorylation of the RelA (p65) NF-kappaB (nuclear factor kappaB) subunit has been previously shown to modulate its ability to induce or repress transcription. In the present study we have investigated the consequences of Thr435 phosphorylation within the C-terminal transactivation domain of RelA. We confirm that Thr435 is phosphorylated in cells and is induced by TNFalpha (tumour necrosis factor alpha)...

Topics

Animals
Blotting, Western
Cell Line
Cell Line, Tumor
Chemokine CXCL2
Gene Expression Regulation
Histone Deacetylase 1
Humans
Immunoprecipitation
Marine Toxins
Mice
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxazoles

Phosphoprotein Phosphatases

Phosphorylation

Protein Binding

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 20001970
DOI: 10.1042/BJ20091630
PMCID: PMC2829238

Genes

HDAC1

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