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Article

Variations of BRAF mutant allele percentage in melanomas.

BMC cancer - 4 Jul 2015

Hélias-Rodzewicz Zofia, Funck-Brentano Elisa, Baudoux Laure, Jung Chan Kwon, Zimmermann Ute, Marin Cristi, Clerici Thierry, Le Gall Catherine, Peschaud Frédérique, Taly Valérie, Saiag Philippe, Emile Jean-François

Abstract excerpt

BACKGROUND: BRAF mutations are present in 40% of human skin melanomas. Mutated tumors with an increased percentage of BRAF mutant alleles (BRAF-M%) may have a better response to RAF/MEK inhibitors. We evaluated the BRAF-M% in melanomas, and the genetic causes of its variation. METHODS: BRAF-M% was quantified by pyrosequencing, real-time PCR (rtPCR) and/or picoliter-droplet PCR (dPCR). BRAF mutant expression was...

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Share to Aneuploidy
Share to Chromosomes, Human, Pair 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 26141748
DOI: 10.1186/s12885-015-1515-3
PMCID: PMC4491198

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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