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Article

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).

Oncogene - 25 Nov 2004

Sevilla Ana, Santos Claudio R, Barcia Ramiro, Vega Francisco M, Lazo Pedro A

Abstract excerpt

The VRK1 kinase is a novel Ser-Thr kinase in the human kinome that diverged from the casein kinase 1 branch. These kinases phosphorylate transcription factors related to stress responses, such as p53. In this report we have studied the phosphorylation of the transcription factor c-Jun in its N-terminal region. The VRK1 protein phosphorylates c-Jun with a Km of 0.4 muM, and is not inhibited by SP600125. VRK1...

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Source

Identifiers

PMID: 15378002
DOI: 10.1038/sj.onc.1208015

Genes

VRK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).PMID 15378002Read ↗

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Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.Semantic proximity Read ↗

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Activation of c-Jun transcription factor by substitution of a charged residue in its N-terminal domain.Semantic proximity Read ↗

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop.Semantic proximity Read ↗

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