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Article

Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire.

Environmental health perspectives - 1 Aug 2007

Applebaum Katie M, Karagas Margaret R, Hunter David J, Catalano Paul J, Byler Steven H, Morris Steve, Nelson Heather H

Abstract excerpt

BACKGROUND: Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer (NMSC). OBJECTIVE: We tested whether polymorphisms in the NER genes XPA (A23G) and XPD (Asp312Asn and Lys751Gln) modify the association between arsenic and NMSC. METHODS: Incident cases of...

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Identifiers

PMID: 17687452
DOI: 10.1289/ehp.10096
PMCID: PMC1940098

Genes

XPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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