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Article

Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline.

Environmental health perspectives - 1 Aug 2007

Wang Florence T, Hu Howard, Schwartz Joel, Weuve Jennifer, Spiro Avron S, Sparrow David, Nie Huiling, Silverman Edwin K, Weiss Scott T, Wright Robert O

Abstract excerpt

BACKGROUND: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. OBJECTIVE: Our goal was to assess the modifying effects of HFE variants on the lead burden and cognitive decline relation in older adults. METHODS: We measured tibia and patella lead using K-X-ray...

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Source

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Identifiers

PMID: 17687449
DOI: 10.1289/ehp.9855
PMCID: PMC1940090

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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