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Article

Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function.

Neurotoxicology - 1 Dec 2013

Eum Ki-Do, Wang Florence T, Schwartz Joel, Hersh Craig P, Kelsey Karl, Wright Robert O, Spiro Avron, Sparrow David, Hu Howard, Weisskopf Marc G

Abstract excerpt

BACKGROUND: Glutathione-S-transferase gene (GST) polymorphisms can result in variable ability of these enzymes to remove electrophilic substrates. We investigated whether the GSTP1 Val105 and GSTM1 deletion polymorphisms modify the lead-cognitive function association. METHODS: We used repeated measures analysis to compare the association between cumulative lead biomarkers-bone lead measured using K-shell X-Ray...

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Identifiers

PMID: 23958642
DOI: 10.1016/j.neuro.2013.08.002
PMCID: PMC3844089

Genes

GSTP1
GSTM1

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