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Article

Modification of the association between lead exposure and amyotrophic lateral sclerosis by iron and oxidative stress related gene polymorphisms.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Mar 2015

Eum Ki-Do, Seals Ryan M, Taylor Kathryn M, Grespin Matthew, Umbach David M, Hu Howard, Sandler Dale P, Kamel Freya, Weisskopf Marc G

Abstract excerpt

Our objective was to examine whether functional polymorphisms in hemochromatosis (HFE; H63D and C282Y), transferrin (TfC2), and glutathione-s-transferase Pi1 (GSTP1; Ile105Val) genes modify any lead-ALS association. We measured blood lead using atomic absorption spectroscopy and bone lead - a biomarker of cumulative lead exposure - using K-shell-X-ray fluorescence in 100 neurologist-confirmed ALS cases and 194...

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Source

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Identifiers

PMID: 25293352
DOI: 10.3109/21678421.2014.964259
PMCID: PMC4467726

Genes

GSTP1
HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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