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Article

APOE ε4 allele modifies the association of lead exposure with age-related cognitive decline in older individuals.

Environmental research - 1 Nov 2016

Prada Diddier, Colicino Elena, Power Melinda C, Weisskopf Marc G, Zhong Jia, Hou Lifang, Spiro Avron, Vokonas Pantel, Brenan Kasey, Herrera Luis A, Schwartz Joel, Wright Robert, Hu Howard, Baccarelli Andrea A

Abstract excerpt

BACKGROUND: Continuing chronic and sporadic high-level of lead exposure in some regions in the U.S. has directed public attention to the effects of lead on human health. Long-term lead exposure has been associated with faster cognitive decline in older individuals; however, genetic susceptibility to lead-related cognitive decline during aging has been poorly studied. METHODS: We determined the interaction of...

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Identifiers

PMID: 27474937
DOI: 10.1016/j.envres.2016.07.034
PMCID: PMC5071136

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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