Article
In vitro drug susceptibility analysis of hepatitis B virus clinical quasispecies populations.
Journal of clinical microbiology - 1 Oct 2007
Zhu Yuao, Curtis Maria, Snow-Lampart Andrea, Yang Huiling, Delaney William, Miller Michael D, Borroto-Esoda Katyna
Abstract excerpt
Analysis of the replication and drug resistance of patient serum hepatitis B virus (HBV) populations can contribute to the therapeutic management of chronic hepatitis B. We developed a procedure for cloning serum HBV quasispecies populations and for phenotypic analysis of the cloned populations for in vitro drug susceptibility. Equivalent sequences were compared to the respective serum HBV DNAs of the cloned...
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