Article
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir.
Antiviral therapy - 1 Jun 2004
Lada Olivier, Benhamou Yves, Cahour Annie, Katlama Christine, Poynard Thierry, Thibault Vincent
Abstract excerpt
Emergence of lamivudine-resistant hepatitis B virus (HBV) is a major concern in human immunodeficiency virus (HIV) and HBV coinfected patients. Following selection of resistant mutants, hepatitis flare or rapid progression to cirrhosis may occur. Treatment of patients with new nucleotide analogues such as adefovir dipivoxil (ADV) or tenofovir disoproxil fumarate (TDF) has shown good efficacy in controlling...
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