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DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2007

Hansen Helen M, Wiemels Joseph L, Wrensch Margaret, Wiencke John K

Abstract excerpt

Whole genome amplification (WGA) permits genotyping DNA samples of limited quantity, expanding the number of samples available for genetic epidemiology studies. WGA, however, produces various nucleic acid side products that may interfere with accurate DNA quantification and further analysis. Although quality control of whole genome amplified DNA (wgaDNA) before genotyping is essential to prevent failed or poor...

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PMID: 17684147
DOI: 10.1158/1055-9965.EPI-06-1024

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