Article
Whole-genome genotyping.
Methods in enzymology - 1 Jan 2006
Gunderson Kevin L, Steemers Frank J, Ren Hongi, Ng Pauline, Zhou Lixin, Tsan Chan, Chang Weihua, Bullis Dave, Musmacker Joe, King Christine, Lebruska Lori L, Barker David, Oliphant Arnold, Kuhn Kenneth M, Shen Richard
Abstract excerpt
We have developed an array-based whole-genome genotyping (WGG) assay (Infinium) using our BeadChip platform that effectively enables unlimited multiplexing and unconstrained single nucleotide polymorphism (SNP) selection. A single tube whole-genome amplification reaction is used to amplify the genome, and loci of interest are captured by specific hybridization of amplified gDNA to 50-mer probe arrays. After...
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