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Article

Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer.

Molecular carcinogenesis - 1 Feb 2008

Van Emburgh Beth O, Hu Jennifer J, Levine Edward A, Mosley Libyadda J, Case L Douglas, Lin Hui-Yi, Knight Sommer N, Perrier Nancy D, Rubin Peter, Sherrill Gary B, Shaw Cindy S, Carey Lisa A, Sawyer Lynda R, Allen Glenn O, Milikowski Clara, Willingham Mark C, Miller Mark Steven

Abstract excerpt

Polymorphisms in phase I and phase II enzymes may enhance the occurrence of mutations at critical tumor suppressor genes, such as p53, and increase breast cancer risk by either increasing the activation or detoxification of carcinogens and/or endogenous estrogens. We analyzed polymorphisms in CYP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17683074
DOI: 10.1002/mc.20365
PMCID: PMC3722359

Genes

GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17683074-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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