Article
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Cancer research - 1 Jun 2001
Ko Y, Abel J, Harth V, Bröde P, Antony C, Donat S, Fischer H P, Ortiz-Pallardo M E, Thier R, Sachinidis A, Vetter H, Bolt H M, Herberhold C, Brüning T
Abstract excerpt
Tobacco use is causally associated with head and neck squamous cell cancer (HNSCC). Here, we present the results of a case-control study that investigated the effects that the genetic variants of the cytochrome (CYP)1A1, CYP1B1, glutathione-S-transferase (GST)M1, GSTT1, and GSTP1 genes have on modifying the risk of smoking-related HNSCC. Allelisms of the CYP1A1, GSTT1, GSTM1, and GSTT1 genes alone were not...
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