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Article

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling.

Molecular and cellular biology - 1 Jun 2005

Ai Minrong, Holmen Sheri L, Van Hul Wim, Williams Bart O, Warman Matthew L

Abstract excerpt

The low-density-lipoprotein receptor-related protein 5 (LRP5), a coreceptor in the canonical Wnt signaling pathway, has been implicated in human disorders of low and high bone mass. Loss-of-function mutations cause the autosomal recessive osteoporosis-pseudoglioma syndrome, and heterozygous misse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15923613
DOI: 10.1128/MCB.25.12.4946-4955.2005
PMCID: PMC1140571

Genes

HBM
DKK1
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15923613-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling.PMID 15923613Read ↗

Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling.Semantic proximity Read ↗

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass.Semantic proximity Read ↗

A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).Semantic proximity Read ↗

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.Semantic proximity Read ↗

The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes.Semantic proximity Read ↗

High bone density due to a mutation in LDL-receptor-related protein 5.Semantic proximity Read ↗

Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling.Semantic proximity Read ↗

Clinical features, treatment, and follow-up of OPPG and high-bone-mass disorders: LRP5 is a key regulator of bone mass.Semantic proximity Read ↗

Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.Semantic proximity Read ↗

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.Semantic proximity Read ↗

Identification of the first deletion in the LRP5 gene in a patient with autosomal dominant osteopetrosis type I.Semantic proximity Read ↗

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivitySemantic proximity Read ↗

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