Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.

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Article

Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.

Diabetes - 1 Feb 1998

Hanifi Moghaddam P, de Knijf P, Roep B O, Van der Auwera B, Naipal A, Gorus F, Schuit F, Giphart M J

Abstract excerpt

We analyzed 11 markers in the IDDM1 region in 120 IDDM patients and 83 healthy control subjects who were fully matched for the highest risk HLA-DQA1*0301-DQB1 *0302/DQA1*0501-DQB1*0201 genotype. Our study provides strong evidence that two regions in the major histocompatibility complex contribute to IDDM susceptibility or protection. First, despite selection for highest IDDM-associated risk DQ genotypes, this...

Topics

Adult
Alleles
Diabetes Mellitus, Type 1
Female
Gene Frequency
Genetic Markers
Genotype
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Linkage Disequilibrium

Major Histocompatibility Complex

Male

Microsatellite Repeats

Polymerase Chain Reaction

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 9519723

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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