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Article

Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis.

Human molecular genetics - 15 Nov 2008

Maxwell James R, Potter Catherine, Hyrich Kimme L, Barton Anne, Worthington Jane, Isaacs John D, Morgan Ann W, Wilson Anthony G

Abstract excerpt

Anti-tumour necrosis factor (TNF) agents have revolutionized the treatment of patients with rheumatoid arthritis (RA). These therapies are, however, expensive and 30% of patients fail to respond. In a large cohort of Caucasian RA patients treated with anti-TNF medications (total n = 1050, etanercept n = 455, infliximab n = 450), we investigated whether genotypes of eight single nucleotide polymorphisms in the...

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Source

Identifiers

PMID: 18713756
DOI: 10.1093/hmg/ddn245

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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