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Article

Hepatitis E virus persists in the presence of a type III interferon response

30 May 2017

Abstract excerpt

The RIG-I-like RNA helicase (RLR)-mediated interferon (IFN) response plays a pivotal role in the hepatic antiviral immunity.The hepatitis A virus (HAV) and the hepatitis C virus (HCV) counter this response by encoding a viral protease that cleaves the mitochondria antiviral signaling protein (MAVS), a common signaling adaptor for RLRs.However, a third hepatotropic RNA virus, the hepatitis E virus (HEV), does not...

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PMID: 28558073
DOI: 10.1371/journal.ppat.1006417

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