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Article

Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver.

mBio - 24 Feb 2015

Mitchell Angela M, Stone Amy E L, Cheng Linling, Ballinger Kimberly, Edwards Michael G, Stoddard Mark, Li Hui, Golden-Mason Lucy, Shaw George M, Khetani Salman, Rosen Hugo R

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) infection leads to persistence in the majority of cases despite triggering complex innate immune responses within the liver. Although hepatocytes are the preferred site for HCV replication, nonparenchymal cells (NPCs) can also contribute to antiviral immunity. Recent innovations involving single-genome amplification (SGA), direct amplicon sequencing, and phylogenetic inference...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25714713
DOI: 10.1128/mBio.02510-14
PMCID: PMC4357998

Genes

STAT1
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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