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Article

Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.

Gastroenterology - 1 Nov 2008

Liang Yuqiong, Ishida Hisashi, Lenz Oliver, Lin Tse-I, Nyanguile Origène, Simmen Kenny, Pyles Richard B, Bourne Nigel, Yi Minkyung, Li Kui, Lemon Stanley M

Abstract excerpt

BACKGROUND & AIMS: Expression of the nonstructural protein (NS)3/4A protease in cells infected with hepatitis C virus (HCV) results in cleavage of the mitochondrial antiviral-signaling protein (MAVS) and disruption of signaling pathways that lead to viral activation of interferon regulatory factor 3 (IRF-3) and synthesis of type 1 interferons (IFN-alpha/beta). High concentrations of inhibitors of NS3/4A reverse...

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Source

Identifiers

PMID: 18725224
DOI: 10.1053/j.gastro.2008.07.023

Genes

MAVS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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