Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes

4 Nov 2021

Abstract excerpt

The liver is targeted by several human pathogenic RNA viruses for viral replication and dissemination; despite this, the extent of innate immune sensing of RNA viruses by human hepatocytes is insufficiently understood to date. In particular, for highly human tropic viruses such as hepatitis C virus, cell culture models are needed to study immune sensing. However, several human hepatoma cell lines have impaired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34831243
DOI: 10.3390/cells10113019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human HepatocytesPMID 34831243Read ↗

Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficienciesSemantic proximity Read ↗

Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells.Semantic proximity Read ↗

Characterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver CellsSemantic proximity Read ↗

Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver.Semantic proximity Read ↗

Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived HepatocytesSemantic proximity Read ↗

Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replicationSemantic proximity Read ↗

Hepatitis E virus persists in the presence of a type III interferon responseSemantic proximity Read ↗

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactionsSemantic proximity Read ↗

Interaction of Hepatitis C virus proteins with pattern recognition receptorsSemantic proximity Read ↗

Hepatitis D virus infection of stem cell-derived hepatocytes triggers an IFN- and NFκB-based innate immune response unable to clear infectionSemantic proximity Read ↗

RIG‐I is a key antiviral interferon‐stimulated gene against hepatitis E virus regardless of interferon productionSemantic proximity Read ↗

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.