Article
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2006
Loo Yueh-Ming, Owen David M, Li Kui, Erickson Andrea K, Johnson Cynthia L, Fish Penny M, Carney D Spencer, Wang Ting, Ishida Hisashi, Yoneyama Mitsutoshi, Fujita Takashi, Saito Takeshi, Lee William M, Hagedorn Curt H, Lau Daryl T-Y, Weinman Steven A, Lemon Stanley M, Gale Michael
Abstract excerpt
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/beta response that limits virus infection. The hepatitis C virus (HCV) NS3/4A protease cleaves IPS-1 to block RIG-I signaling, but how this regulation controls the host response to HCV is not known. Moreover, endogenous IPS-1...
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