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Article

Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells.

Journal of virology - 1 Oct 2009

Wang Nan, Liang Yuqiong, Devaraj Santhana, Wang Jie, Lemon Stanley M, Li Kui

Abstract excerpt

Toll-like receptor-3 (TLR3) senses double-stranded RNA, initiating signaling that activates NF-kappaB and interferon regulatory factor 3 (IRF-3), thereby inducing the synthesis of proinflammatory cytokines, type I interferons, and numerous interferon-stimulated genes (ISGs). This pathway has not been extensively investigated in human hepatocytes, and its role in sensing and protecting against hepatitis virus...

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Source

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Identifiers

PMID: 19625408
DOI: 10.1128/JVI.01125-09
PMCID: PMC2747996

Genes

TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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