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Article

Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas.

Cancer causes & control : CCC - 1 Nov 2007

Terry Mary Beth, Gammon Marilie D, Zhang Fang Fang, Vaughan Thomas L, Chow Wong-Ho, Risch Harvey A, Schoenberg Janet B, Mayne Susan T, Stanford Janet L, West A Brian, Rotterdam Heidi, Blot William J, Fraumeni Joseph F, Santella Regina M

Abstract excerpt

OBJECTIVES: Alcohol increases esophageal squamous carcinoma risk but has been less consistently associated with esophageal adenocarcinoma. Alcohol dehydrogenase catalyzes the oxidation of approximately 80% of ethanol to acetaldehyde, a carcinogen. The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk. METHODS: We...

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PMID: 17665311
DOI: 10.1007/s10552-007-9046-0

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