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Article

Ultraconserved non‐coding sequence element controls a subset of spatiotemporal GLI3 expression

27 Jul 2007

Abstract excerpt

The zinc-finger transcription factor GLI3 acts during vertebrate development in a combinatorial, context-dependent fashion as a primary transducer of sonic hedgehog (SHH) signaling. In humans, mutations affecting this key regulator of development are associated with GLI3-morphopathies, a group of congenital malformations in which forebrain and limb development are preferentially affected. We show that a...

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PMID: 17661744
DOI: 10.1111/j.1440-169x.2007.00954.x

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