Transporter Hypothesis of Drug-Resistant Epilepsy: Challenges for Pharmacogenetic Approaches

Abstract excerpt

Drug resistance in epilepsy is considered a complex and multifactorial problem. Overexpression of efflux transporters at the blood-brain barrier is discussed as one factor that might limit brain penetration and efficacy of antiepileptic drugs. Whereas experimental data render support for this hypothesis, there is still a lack of sufficient clinical evidence indicating a functional role of efflux transporters....

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