Intestinal tumorigenicity of mice carrying hemizygous Pax6, Pax6(Sey-4H).

doi:10.1538/expanim.56.289

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Article

Intestinal tumorigenicity of mice carrying hemizygous Pax6, Pax6(Sey-4H).

Experimental animals - 1 Jul 2007

Nitta Yumiko, Yoshida Kazuko, Nakagata Naomi, Nitta Kohsaku, Harada Toshihide, Ishizaki Fumiko

Abstract excerpt

The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6(Sey-4H), which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are located. Expecting the development of myeloid leukemia,...

Topics

Adenocarcinoma
Adenoma
Animals
Eye Proteins
Female
Gastrointestinal Neoplasms
Gene Silencing
Genetic Predisposition to Disease
Heterozygote
Homeodomain Proteins
Mice
Mice, Inbred C3H
Mice, Knockout
Mice, Mutant Strains
Neoplasms, Radiation-Induced

Source

Open in PubMed

Identifiers

PMID: 17660683
DOI: 10.1538/expanim.56.289

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PAX6 Transcription Factor

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Radionuclide Imaging