Article

Saposin-related gene function as tumor suppressor in tracheal system of Drosophila larvae via Hippo signaling pathway: Novel gene to gene network prediction with GeneMANIA

2023-11-07

Abstract excerpt

Saposin-related ( Sap-R ) proteins promote the hydrolases of sphingolipids in lysosomes. Disrupted human Sap-R functions may lead to death at an early age. More worse, effective therapeutics are not available due to poorly understood molecular underlying mechanisms. To gain more insights about these mechanisms, we utilized Drosophila melanogaster as a simple invertebrate model with available genetic tools, with sp...

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Literature Corpus work: f599a201-1996-5937-846d-b1990593fe7d
DOI: 10.21203/rs.3.rs-3489166/v1

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