Article
Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.
Genetics - 1 Jul 2008
Favor Jack, Gloeckner Christian Johannes, Neuhäuser-Klaus Angelika, Pretsch Walter, Sandulache Rodica, Saule Simon, Zaus Irmgard
Abstract excerpt
In this study we extend the mouse Pax6 mutant allelic series to include a homozygous and hemizygous viable hypomorph allele. The Pax6(132-14Neu) allele is a Phe272Ile missense mutation within the third helix of the homeodomain. The mutant Pax6 homeodomain shows greatly reduced binding activity to the P3 DNA binding target. Glucagon-promoter activation by the entire mutant Pax6 product of a reporter gene driven by...
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