Spontaneous and radiation-induced leukemogenesis of the mouse small eye mutant, Pax6(Sey3H).

doi:10.1269/jrr.45.245

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Article

Spontaneous and radiation-induced leukemogenesis of the mouse small eye mutant, Pax6(Sey3H).

Journal of radiation research - 1 Jun 2004

Nitta Yumiko, Yoshida Kazuko, Satoh Kenichi, Senba Kei, Nakagata Naomi, Peters Jo, Cattanach Bruce M

Abstract excerpt

Allelic loss on the chromosome 2 is associated with radiation-induced murine acute myeloid leukemia. However, the gene, which contributes mainly to the leukemogenesis has not yet been identified. Expecting any predisposition to acute myeloid leukemia, we performed a radiation leukemogenensis experiment with Pax6(Sey3H), one of the small eye mutants carrying a congenital hemizygosity of the chromosome 2 middle...

Topics

Animals
Aniridia
Eye Proteins
Gamma Rays
Genetic Predisposition to Disease
Homeodomain Proteins
Intestinal Neoplasms
Leukemia, Myeloid, Acute
Leukemia, Radiation-Induced
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

PAX6 Transcription Factor

Paired Box Transcription Factors

Repressor Proteins

Survival

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 15304967
DOI: 10.1269/jrr.45.245

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