A mouse model of the aniridia-Wilms tumor deletion syndrome.

doi:10.1126/science.2173141

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Article

A mouse model of the aniridia-Wilms tumor deletion syndrome.

Science (New York, N.Y.) - 9 Nov 1990

Glaser T, Lane J, Housman D

Abstract excerpt

Deletion of chromosome 11p13 in humans produces the WAGR syndrome, consisting of aniridia (an absence or malformation of the iris), Wilms tumor (nephroblastoma), genitourinary malformations, and mental retardation. An interspecies backcross between Mus musculus/domesticus and Mus spretus was made...

Topics

Animals
Aniridia
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
DNA
Disease Models, Animal
Eye
Female
Genes, Wilms Tumor
Genetic Markers
Kidney Neoplasms
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Muridae
Mutation

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