Article
Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters.
Investigative ophthalmology & visual science - 1 Dec 2005
Graw Jochen, Löster Jana, Puk Oliver, Münster Doris, Haubst Nicole, Soewarto Dian, Fuchs Helmut, Meyer Birgit, Nürnberg Peter, Pretsch Walter, Selby Paul, Favor Jack, Wolf Eckhard, Hrabé de Angelis Martin
Abstract excerpt
PURPOSE: To characterize three new mouse small-eye mutants detected during ethylnitrosourea mutagenesis programs. METHODS: Three new mouse small-eye mutants were morphologically characterized, particularly by in situ hybridization. The mutations were mapped, and the candidate gene was sequenced. The relative amount of Pax6-specific mRNA was determined by real-time PCR. Reporter gene analysis used Crygf and Six3...
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