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Article

Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1.

Genetics - 1 Sept 2007

Mutiu A Irina, Hoke Stephen M T, Genereaux Julie, Hannam Carol, MacKenzie Katherine, Jobin-Robitaille Olivier, Guzzo Julie, Côté Jacques, Andrews Brenda, Haniford David B, Brandl Christopher J

Abstract excerpt

Tra1 is an essential component of the Saccharomyces cerevisiae SAGA and NuA4 complexes. Using targeted mutagenesis, we identified residues within its C-terminal phosphatidylinositol-3-kinase (PI3K) domain that are required for function. The phenotypes of tra1-P3408A, S3463A, and SRR3413-3415AAA included temperature sensitivity and reduced growth in media containing 6% ethanol or calcofluor white or depleted of...

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Identifiers

PMID: 17660562
DOI: 10.1534/genetics.107.074476
PMCID: PMC2013730

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