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Article

Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.

Molecular and cellular biology - 1 Feb 2011

Knutson Bruce A, Hahn Steven

Abstract excerpt

The Tra1 protein is a direct transcription activator target that is essential for coactivator function of both the SAGA and NuA4 histone acetyltransferase (HAT) complexes. The ∼400-kDa Saccharomyces cerevisiae Tra1 polypeptide and its human counterpart TRRAP contain 67 or 68 tandem α-helical HEAT and TPR protein repeats that extend from the N terminus to the conserved yet catalytically inactive...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Genes, Fungal
Share to Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Protein Stability

Share to Structural Homology, Protein

Share to Trans-Activators

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 21149579
DOI: 10.1128/MCB.00687-10
PMCID: PMC3028633

Genes

TPR
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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