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Article

A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae.

Genetics - 1 Sept 2007

James Nicole, Landrieux Emilie, Collart Martine A

Abstract excerpt

The conserved multi-subunit Ccr4-Not complex regulates gene expression in diverse ways. In this work, we characterize the suppression of temperature sensitivity associated with a mutation in the gene encoding the scaffold subunit of the Ccr4-Not complex, NOT1, by the deletion of SPT3. We determine that the deletion of SPT3, but not the deletion of genes encoding other subunits of the SAGA complex, globally...

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Identifiers

PMID: 17660549
DOI: 10.1534/genetics.107.076299
PMCID: PMC2013695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae.PMID 17660549Read ↗

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.Semantic proximity Read ↗

The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.Semantic proximity Read ↗

The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.Semantic proximity Read ↗

Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.Semantic proximity Read ↗

The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit.Semantic proximity Read ↗

The Ccr4-not complex regulates Skn7 through Srb10 kinase.Semantic proximity Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.Semantic proximity Read ↗

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