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Article

Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex.

Journal of molecular biology - 6 Sept 2002

Russell Pamela, Benson John D, Denis Clyde L

Abstract excerpt

The NOT2 protein is a component of the CCR4-NOT complex that plays multiple roles in the regulation of mRNA production in the yeast Saccharomyces cerevisiae. We have identified four novel not2 mutations and have characterized these and two previously described alleles as to the means by which they affect CCR4-NOT function. While two of the not2 alleles, not2-4 (carrying a G31R alteration) and not2::L9P, resulted...

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Source

Identifiers

PMID: 12215412
DOI: 10.1016/s0022-2836(02)00707-6

Genes

CCR4
ADA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex.PMID 12215412Read ↗

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Semantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

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Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.Semantic proximity Read ↗

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The essential function of Not1 lies within the Ccr4-Not complex.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

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